알츠하이머 질환과 관련된 타액 생체표지자
Salivary biomarkers related to Alzheimer's disease
고홍섭,
소속 상세정보
고홍섭 ( Kho Hong-Seop ) - 서울대학교 치의학대학원 구강내과진단학교실
KMID : 1033920170130010001
Abstract
There have been several publications regarding salivary biomarkers related to Alzheimer's disease. These studies have been performed based on the following scientific knowledge: 1) salivary flow is regulated and influenced by cranial nerves, 2) cerebrospinal biomarkers for Alzheimer's disease are also expressed in the salivary glands, and 3) the anatomical proximity of orofacial structures to brain and their probable communications through cranial nerves and blood vessels. The reported biomarkers were salivary acetylcholinesterase, beta amyloid, tau, lactoferrin, and trehalose. These results showed promising possibilities for future clinical use, though the number of studies is too small and there is still inconsistency in the reported results. Further studies are necessary based on the concepts of multi-analyte system and/or point-of-care.
키워드
Alzheimer; Biomarker; Saliva
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